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Hello Kenneth Gregie
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Since the warning returns every week, the next step is to identify exactly which file is triggering it rather than changing the global macro settings.
Does the warning appear only when you open a particular workbook, or does it appear as soon as Excel starts?
Also, where are the macros stored: inside the affected workbook, PERSONAL.XLSB, a template, or an Excel add-in?
Please provide the file extension and general storage location, such as a local folder, OneDrive, an email attachment, or a network drive, without including personal information.
If this is a work- or school-managed computer, an administrator policy may be enforcing the block. In that case, Trust Center changes might not override it, so your IT administrator would need to review the Excel macro policy.
For macros that you own and use regularly, digitally signing the VBA project and trusting that publisher may also provide a safer long-term solution than repeatedly unblocking files.
Please do not select Enable all macros, as that would reduce protection for every workbook opened in Excel.
I look forward to your update and will be happy to guide you further.